Research
Mixed
Among FDA-approved pharmacological treatments for obesity, phentermine-topiramate and liraglutide are associated with the highest probability of achieving at least 5% weight loss at 52 weeks compared to placebo.
If you are considering medication for obesity, phentermine-topiramate and liraglutide currently offer the highest likelihood of losing at least 5% of your body weight within a year compared to other approved options. Be aware that these same medications also carry a higher risk of stopping treatment due to side effects.
GoodSupportsHIGH confidence
Phentermine-topiramate and liraglutide were associated with the highest odds of achieving at least 5% weight loss.
Why this rating
High-quality network meta-analysis of 28 RCTs, though limited by high attrition rates (30-45%).
Source
Association of Pharmacological Treatments for Obesity With Weight Loss and Adverse Events
Rohan Khera et al. · JAMA · 2016
Meta-analysis · 28 studiesCited 849×
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