Research
Mixed
Higher microbiome diversity is associated with a 'health-related' cluster of host factors (e.g., higher HDL, vitamin D, physical activity) and lower abundance of certain pathogenic genera, while lower diversity is linked to a 'disease-related' cluster (e.g., high BMI, inflammation, diabetes markers).
Focus on building a diverse microbiome through a mix of healthy behaviors: eat plenty of fruits, vegetables, and whole grains, stay physically active, and manage stress. This holistic approach is associated with better clinical health markers and a more resilient gut ecosystem.
GoodSupportsHIGH confidence
The first is a health-related group, where higher values of the host factors or increased cadence of lifestyle behaviors are generally associated with better overall health... The second is a disease-related group, in which higher values of the host factors or increased cadence of lifestyle behaviors are generally associated with worse overall health...
Why this rating
Large cohort, extensive phenotyping (150 factors), robust statistical methods.
Source
Health and disease markers correlate with gut microbiome composition across thousands of people
Ohad Manor et al. · Nature Communications · 2020
DOI 10.1038/s41467-020-18871-1
cross_sectional · n=3409Cited 845×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Higher levels of moderate and vigorous physical activity are robustly associated with increased gut microbiome diversity, independent of major dietary factors and BMI.Good
- The association between specific gut bacteria (e.g., Faecalibacterium, Lachnospira) and health markers is robust and independent of overall microbiome diversity, whereas associations with other bacteria (e.g., Ruminococcaceae) are largely driven by overall diversity.Good
Related findings · Mixed
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This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →