Research

Mixed

Gut microbiota transplantation from high-cholesterol diet-fed mice to germ-free mice is sufficient to induce hepatic lipid accumulation, inflammation, and cell proliferation, demonstrating a causal role for microbiota in NAFLD-HCC.

Your gut bacteria are not just passengers; they can drive liver disease. If your diet has altered your gut bacteria to favor harmful types, those bacteria can directly cause liver inflammation and fat accumulation, even if you change your diet later.

StrongSupportsHIGH confidence
Germ- free mice gavaged with stools from mice fed HFHC manifested hepatic lipid accumulation, inflammation and cell proliferation.
Xiang Zhang et al. · Gut · 2020

Why this rating

Germ-free mouse model provides high causal evidence for microbiota involvement.

Source

Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites

Xiang Zhang et al. · Gut · 2020

mechanism_only · n=98Cited 843×
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