Research
Mixed
Gut microbiota transplantation from high-cholesterol diet-fed mice to germ-free mice is sufficient to induce hepatic lipid accumulation, inflammation, and cell proliferation, demonstrating a causal role for microbiota in NAFLD-HCC.
Your gut bacteria are not just passengers; they can drive liver disease. If your diet has altered your gut bacteria to favor harmful types, those bacteria can directly cause liver inflammation and fat accumulation, even if you change your diet later.
StrongSupportsHIGH confidence
Germ- free mice gavaged with stools from mice fed HFHC manifested hepatic lipid accumulation, inflammation and cell proliferation.
Why this rating
Germ-free mouse model provides high causal evidence for microbiota involvement.
Source
Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites
Xiang Zhang et al. · Gut · 2020
DOI 10.1136/gutjnl-2019-319664
mechanism_only · n=98Cited 843×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- High dietary cholesterol drives the sequential progression of non-alcoholic fatty liver disease (NAFLD) to hepatocellular carcinoma (HCC) by inducing gut microbiota dysbiosis and altering metabolites, specifically increasing taurocholic acid and decreasing 3-indolepropionic acid.Good
- Cholesterol-lowering therapy with atorvastatin completely prevents NAFLD-HCC development in high-cholesterol diet-fed mice by restoring gut microbiota dysbiosis.Good
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