Hormonal
Liraglutide treatment in combination with metformin and TZD leads to significant reductions in systolic blood pressure and favorable changes in lipid profiles (specifically free fatty acids, LDL, and triglycerides) compared to placebo.
If you are taking metformin and a TZD for Type 2 Diabetes, adding liraglutide (1.2 or 1.8 mg once daily) can also help lower your blood pressure and improve your cholesterol levels (specifically LDL and triglycerides). This adds cardiovascular benefits to the blood sugar and weight control benefits. Be aware that you might experience some nausea, but it usually gets better over time.
Systolic blood pressure decreased by 6.7, 5.6, and 1.1 mmHg with 1.2 and 1.8 mg liraglutide and placebo, respectively... LDL cholesterol and triglycerides decreased significantly more in the 1.2 mg liraglutide group than in the placebo group.
Why this rating
Large-scale, double-blind, placebo-controlled, randomized trial.
Source
Efficacy and Safety of the Human Glucagon-Like Peptide-1 Analog Liraglutide in Combination With Metformin and Thiazolidinedione in Patients With Type 2 Diabetes (LEAD-4 Met+TZD)
Bernard Zinman et al. · Diabetes Care · 2009
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →