Research

Micronutrients & recovery

The protective effect of high folate intake against coronary heart disease is significantly stronger in women who consume alcohol, particularly those drinking more than one drink per day.

If you are a woman who drinks alcohol, ensuring you have high levels of folate and vitamin B6 is particularly important. The study found that the heart-protective benefits of these vitamins were strongest in women who drank more than one drink per day. This suggests that alcohol consumers should pay extra attention to their B-vitamin intake, potentially through diet or supplements.

ModerateQualifiesMEDIUM confidence
In a subgroup analysis, compared with nondrinkers, the inverse association between a high-folate diet and CHD was strongest among women who consumed up to 1 alcoholic beverage per day (RR =0.69; 95% CI, 0.49-0.97) or more than 1 drink per day (RR=0.27; 95% CI, 0.13-0.58).
Eric B. Rimm · JAMA · 1998

Why this rating

Subgroup analysis within a large observational study. While the trend is strong, subgroup analyses are prone to chance findings and require validation.

Source

Folate and Vitamin B<SUB>6</SUB> From Diet and Supplements in Relation to Risk of Coronary Heart Disease Among Women

Eric B. Rimm · JAMA · 1998

cohort · n=80082Cited 827×
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