Research
Hormonal
Loss-of-function mutations in PPARγ cause a syndrome of partial lipodystrophy and severe insulin resistance, demonstrating that PPARγ is essential for normal adipose tissue function and metabolic health.
This node describes a rare genetic condition, not a general lifestyle advice. It proves that healthy fat tissue is crucial for preventing diabetes.
StrongSupportsVERY_HIGH confidence
The discovery of both rare and severely deleterious dominant-negative mutations leading to a stereotyped syndrome of partial lipodystrophy and severe insulin resistance...
Why this rating
Based on genetic analysis of multiple pedigrees showing a stereotyped, severe phenotype.
Source
PPAR and human metabolic disease
Robert K. Semple · Journal of Clinical Investigation · 2006
DOI 10.1172/jci28003
narrative_reviewCited 820×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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