Hormonal
In non-insulin-dependent diabetes mellitus (NIDDM), insulin resistance is a general characteristic affecting both glucose and free fatty acid (FFA) metabolism, involving impaired suppression of hepatic glucose production and FFA turnover.
For individuals with NIDDM, insulin resistance is not just about blood sugar; it extends to how the body handles fats. High rates of fat oxidation can worsen glucose control and liver glucose production. Managing lipid metabolism is as critical as managing glucose.
In conclusion, our findings demonstrate that insulin resistance is a general characteristic of glucose and FFA metabolism in NIDDM, and involves both oxidative and nonoxidative pathways.
Why this rating
The study uses rigorous methods (euglycemic insulin clamp, indirect calorimetry, isotope tracers) on a controlled cohort.
Source
Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance.
Per‐Henrik Groop et al. · Journal of Clinical Investigation · 1989
DOI 10.1172/jci114142
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