Research
Hormonal
Increased rates of free fatty acid (FFA) and lipid oxidation contribute to impaired suppression of hepatic glucose production (HGP) and diminished stimulation of glucose oxidation by insulin in NIDDM patients.
In NIDDM, high fat oxidation interferes with insulin's ability to suppress liver glucose output and promote glucose use. This suggests that strategies lowering lipid oxidation might improve insulin sensitivity.
GoodConditionalHIGH confidence
The data also demonstrate that FFA/lipid and glucose metabolism are interrelated in NIDDM, and suggest that an increased rate of FFA/lipid oxidation may contribute to the impaired suppression of HGP and diminished stimulation of glucose oxidation by insulin in these patients.
Why this rating
Strong correlation data and mechanistic explanation provided, but causality is suggested ('suggest that') rather than definitively proven.
Source
Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance.
Per‐Henrik Groop et al. · Journal of Clinical Investigation · 1989
DOI 10.1172/jci114142
crossover · n=17Cited 804×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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