Research
Energy balance
Creatine supplementation has potential therapeutic benefits in various clinical populations, including neurodegenerative diseases, creatine synthesis deficiencies, and brain/spinal cord injury.
For specific medical conditions like creatine synthesis deficiencies, high-dose creatine may be beneficial under medical supervision. For general health, 3g/day may offer long-term benefits.
GoodSupportsMEDIUM confidence
a number of researchers have been investigating the potential therapeutic benefits of creatine supplementation in various clinical populations... These studies show that short and long-term supplementation (up to 30 g/day for 5 years) is safe and well-tolerated in healthy individuals and in a number of patient populations ranging from infants to the elderly.
Why this rating
Based on animal studies and some human trials, but less extensive than performance data.
Source
International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine
Richard B. Kreider et al. · Journal of the International Society of Sports Nutrition · 2017
DOI 10.1186/s12970-017-0173-z
narrative_reviewCited 797×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Creatine monohydrate supplementation (5g/day for 5-7 days, followed by 3-5g/day maintenance) significantly increases intramuscular creatine and phosphocreatine stores, leading to enhanced high-intensity exercise performance, greater training adaptations, and increased lean body mass in athletes.Strong
- Creatine supplementation reduces the incidence of musculoskeletal injuries, dehydration, and muscle cramping in athletes during training and competition.Good
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