Energy balance
Excessive intake of carbohydrates (especially mono and disaccharides) combined with positive energy balance disrupts palmitic acid homeostasis, leading to increased tissue PA, dyslipidemia, and inflammation via Toll-like receptor 4.
If you eat too many calories and sugars, your body will convert the excess sugar into fat (palmitic acid) in your liver, even if you don't eat much saturated fat. This leads to inflammation and metabolic issues. To avoid this, focus on energy balance and reducing simple sugars, not just cutting saturated fat.
in presence of other factors such as positive energy balance, excessive intake of carbohydrates (in particular mono and disaccharides), and a sedentary lifestyle, the mechanisms to maintain a steady state of PA concentration may be disrupted leading to an over accumulation of tissue PA resulting in dyslipidemia, hyperglycemia, increased ectopic fat accumulation and increased inflammatory tone via toll-like receptor 4.
Why this rating
The review synthesizes evidence linking DNL, carbohydrate intake, and metabolic outcomes, citing multiple studies on NAFLD and insulin resistance.
Source
Palmitic Acid: Physiological Role, Metabolism and Nutritional Implications
Gianfranca Carta et al. · Frontiers in Physiology · 2017
DOI 10.3389/fphys.2017.00902
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