Mixed
Oral administration of live Parabacteroides goldsteinii reduces obesity, improves insulin sensitivity, and enhances thermogenesis in high-fat diet-fed mice.
This study suggests that Parabacteroides goldsteinii is a beneficial gut bacterium that can help reduce obesity and improve metabolic health. While you cannot currently buy this specific strain as a commercial probiotic supplement, the findings highlight the importance of supporting beneficial gut bacteria through diet (prebiotics) to potentially improve metabolic health.
notably, oral treatment of HFD-fed mice with live P. goldsteinii reduced obesity and was associated with increased adipose tissue thermogenesis, enhanced intestinal integrity and reduced levels of inflammation and insulin resistance.
Why this rating
Strong mechanistic evidence in mice, including direct bacterial administration and FMT experiments.
Source
Gut commensal <i>Parabacteroides goldsteinii</i> plays a predominant role in the anti-obesity effects of polysaccharides isolated from <i>Hirsutella sinensis</i>
Tsung-Ru Wu et al. · Gut · 2018
DOI 10.1136/gutjnl-2017-315458
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →