Research

Energy balance

Obesity is associated with a gut microbiota composition characterized by a higher Firmicutes-to-Bacteroidetes ratio and an increased capacity for energy harvest, which contributes to host adiposity.

Your gut bacteria may be more efficient at extracting energy from food than those of lean individuals, potentially contributing to weight gain. While you cannot directly 'eat' a new microbiome, the paper suggests that weight loss and dietary changes can alter this composition, potentially reducing this efficiency.

GoodSupportsHIGH confidence
Studies of the effect of excess body fat on the abundances of different bacteria taxa in the gut generally show alterations in the gastrointestinal microbiota... obesity was associated with a depletion of Bacteroidetes, together with an enrichment in carbohydrate and lipid-utilizing genes in the microbiome as a whole.
Ruth E. Ley · Current Opinion in Gastroenterology · 2009

Why this rating

Based on multiple human and animal studies cited, though human results show variability.

Source

Obesity and the human microbiome

Ruth E. Ley · Current Opinion in Gastroenterology · 2009

DOI 10.1097/mog.0b013e328333d751

narrative_reviewCited 771×
Read the paper
DOI resolved against Crossref · corpus check 2026-06-10

This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →