Research

Mixed

Epigenetic clocks, particularly those tuned to phenotypic age or mortality risk (e.g., GrimAge), are robust biomarkers for predicting biological aging and adverse health outcomes.

Epigenetic clocks offer a promising way to measure biological age, potentially identifying those aging faster than their chronological age. This could guide personalized interventions to slow aging, though clinical application is still emerging.

StrongSupportsHIGH confidence
A recent literature suggests that hydroxymethylcytosine (5hmC)... is a novel DNA epigenetic modulator... Overall, DNA methylation is emerging as one of the most robust biomarkers of 'biological aging'...
Luigi Ferrucci et al. · Aging Cell · 2019

Why this rating

Strong observational evidence across multiple populations and tissues.

Source

Measuring biological aging in humans: A quest

Luigi Ferrucci et al. · Aging Cell · 2019

narrative_reviewCited 769×
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