Macro partitioning
Liver PPAR-gamma is essential for triglyceride clearance; its absence causes hyperlipidemia and insulin resistance even when hepatic steatosis is reduced.
Do not assume that reducing liver fat automatically improves metabolic health. The liver plays a critical role in clearing triglycerides from the blood. If the mechanism for this clearance (PPAR-gamma) is impaired, reducing liver fat can actually worsen insulin resistance and heart disease risk by forcing lipids into other tissues like muscle and fat.
Inactivation of liver PPAR-gamma reduced the hepatic steatosis but worsened the hyperlipidemia, triglyceride clearance, and muscle insulin resistance.
Why this rating
High-quality mechanistic evidence using specific knockout models (AZIP LKO) with rigorous metabolic clamping.
Source
Liver Peroxisome Proliferator-activated Receptor γ Contributes to Hepatic Steatosis, Triglyceride Clearance, and Regulation of Body Fat Mass
Oksana Gavrilova et al. · Journal of Biological Chemistry · 2003
DOI 10.1074/jbc.m300043200
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