Macro partitioning
Liver PPAR-gamma protects extra-hepatic tissues from triglyceride accumulation and insulin resistance by facilitating hepatic lipid clearance.
Your liver's ability to clear fats from your blood is critical for your muscle health. If your liver cannot process lipids efficiently (due to low PPAR-gamma activity), those fats accumulate in your muscles, leading to insulin resistance and metabolic disease, even if your liver itself looks healthy.
Thus, liver PPAR-gamma regulates triglyceride homeostasis, contributing to hepatic steatosis, but protecting other tissues from triglyceride accumulation and insulin resistance.
Why this rating
Strong mechanistic evidence linking liver function to muscle insulin sensitivity.
Source
Liver Peroxisome Proliferator-activated Receptor γ Contributes to Hepatic Steatosis, Triglyceride Clearance, and Regulation of Body Fat Mass
Oksana Gavrilova et al. · Journal of Biological Chemistry · 2003
DOI 10.1074/jbc.m300043200
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