Hormonal
Activation of SIRT1, SIRT3, and SIRT6 improves glucose metabolism and insulin sensitivity through mechanisms involving AMPK activation, NF-kB inhibition, and regulation of transcription factors like FoxO1 and PGC1α.
While specific SIRT-activating supplements are marketed, the most reliable way to support SIRT activity and metabolic health is through exercise and maintaining metabolic balance. The paper highlights that exercise improves SIRT6-mediated insulin signaling and that SIRT1 activation via AMPK helps glucose tolerance. Focus on consistent physical activity and metabolic health rather than unproven supplements.
SIRT1 is a key positive regulator of systemic insulin sensitivity and regulates pancreatic insulin secretion, thus contributing to increased systemic insulin sensitivity, which triggers glucose uptake and utilization. Mechanistically, SIRT1 participates in the regulation of glucose metabolism by upregulating AMPK, and activation of AMPK can ameliorate the glucose metabolic imbalance.
Why this rating
The paper is a review summarizing multiple studies (in vitro, in vivo, and some human trials), but lacks a single definitive large-scale clinical trial for specific SIRT modulators in humans.
Source
The sirtuin family in health and disease
Qi‐Jun Wu et al. · Signal Transduction and Targeted Therapy · 2022
DOI 10.1038/s41392-022-01257-8
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