Research
Hormonal
SIRTs (particularly SIRT1, SIRT2, SIRT6, and SIRT7) exert anti-inflammatory effects by inhibiting the NF-kB pathway and reducing pro-inflammatory cytokines like TNF-alpha and IL-6.
Chronic inflammation is a risk factor for many diseases. SIRTs help regulate this process. While specific SIRT activators are not yet standard therapy, lifestyle factors that support SIRT activity (like exercise) may help manage inflammatory markers naturally.
ModerateSupportsMEDIUM confidence
Most members of the SIRT family are involved in regulation of the NF-kB pathway... SIRT1 has anti-inflammatory effects mediated by the deacetylation and inactivation of the p65 subunit of NF-kB.
Why this rating
Review of mechanistic studies; some contradictory findings for SIRT2 and SIRT7 are noted.
Source
The sirtuin family in health and disease
Qi‐Jun Wu et al. · Signal Transduction and Targeted Therapy · 2022
DOI 10.1038/s41392-022-01257-8
narrative_reviewCited 764×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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