Research
Mixed
Higher genetic predisposition to obesity, measured by BMI-related loci, interacts with lifestyle factors (specifically SSB intake, fried food, and sedentary behavior) to exponentially increase obesity risk, but healthy lifestyle choices can attenuate this genetic risk.
If you have a family history of obesity, focus on healthy lifestyle choices like limiting SSBs, avoiding fried foods, and staying physically active. These choices can significantly reduce your genetic risk of becoming obese.
GoodConditionalHIGH confidence
Increasing genetic risk at 32 BMI-related loci, coupled with higher SSB consumption, resulted in an exponentially higher risk of obesity... healthy lifestyle choices mitigate genetic risk.
Why this rating
Based on large consortia studies (GIANT, NHS, HPFS) with genome-wide association data and replication cohorts.
Source
Determinants and Consequences of Obesity
Adela Hruby et al. · American Journal of Public Health · 2016
narrative_review · n=238372Cited 745×
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