Energy balance
Caloric restriction and exercise training can reverse metabolic inflexibility by enhancing mitochondrial function and promoting the expression of key metabolic regulators like PGC1α and AMPK.
Regular exercise and controlled caloric intake are proven ways to improve your body's metabolic flexibility. Exercise triggers signals (like AMPK and PGC1α) that boost mitochondrial function and insulin sensitivity. Consistent application of these lifestyle factors can help reverse metabolic inflexibility associated with obesity and type 2 diabetes.
Metabolic flexibility pathways are therapeutic targets for age-related diseases similar to caloric restriction or exercise... During acute exercise, an increased AMP/ATP ratio, sensed by AMPK, increases transcription, translation, and activity of the transcriptional coactivator PPAR gamma coactivator 1-alpha (PGC1α)... The increase of mitochondrial biogenesis and FAO improves insulin sensitivity.
Why this rating
Review of multiple studies showing consistent mechanistic links between lifestyle and metabolic flexibility.
Source
Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease
Reuben L. Smith et al. · Endocrine Reviews · 2018
DOI 10.1210/er.2017-00211
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