Mixed
Patients with non-alcoholic steatohepatitis (NASH) exhibit a significantly lower relative abundance of Bacteroidetes in their intestinal microbiota compared to healthy controls and those with simple steatosis, an association that persists independently of BMI and dietary fat intake.
If you have NASH, your gut bacteria profile is likely distinct from healthy individuals, specifically showing lower levels of Bacteroidetes. This difference is not just because of being overweight or eating fat, but is linked to the liver inflammation itself. While this paper doesn't prescribe a fix, it highlights that restoring gut balance (potentially through fiber or specific prebiotics that support Bacteroidetes) might be a relevant therapeutic avenue to discuss with your hepatologist, separate from weight loss efforts.
Patients with NASH had a lower percentage of Bacteroidetes (Bacteroidetes to total bacteria counts) compared to both SS and HC (p=0.006)... The difference in C. coccoides was no longer significant after adjusting for BMI and fat intake. However, there continued to be a significant association between the presence of NASH and lower percentage Bacteroidetes even after adjusting for these variables (p= 0.002; 95% CI= -0.06 to -0.02).
Why this rating
Cross-sectional design limits causal inference; however, the use of biopsy-proven diagnosis and adjustment for key confounders strengthens the association.
Source
Intestinal microbiota in patients with nonalcoholic fatty liver disease
Marialena Mouzaki et al. · Hepatology · 2013
DOI 10.1002/hep.26319
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