Hormonal
Administration of antiangiogenic agents (specifically angiostatin, endostatin, or TNP-470) induces dose-dependent, reversible weight loss and adipose tissue loss in obese animal models without reducing food intake.
This research suggests that blocking the blood vessel growth required for fat tissue expansion can cause fat loss even if you eat the same amount of food. While this is currently only proven in mice using specific drugs (like angiostatin or endostatin), it implies that future treatments might target the blood supply to fat cells rather than just focusing on diet and exercise.
administration of angiostatin, endostatin, and TNP-470 in both genetically obese and high-calorie diet–fed mice results in a dose-dependent and reversible weight reduction as well as adipose tissue loss without significantly affecting food intakes
Why this rating
Evidence is derived from animal models (genetically obese and diet-induced mice); human clinical data is not provided in this review.
Source
Angiogenesis modulates adipogenesis and obesity
Yihai Cao · Journal of Clinical Investigation · 2007
DOI 10.1172/jci32239
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