Research
Hormonal
Adipose tissue expansion is dependent on angiogenesis; therefore, inhibiting angiogenesis prevents or reverses obesity by causing adipocyte apoptosis and reducing fat mass.
Fat tissue needs blood vessels to grow. If you stop the growth of new blood vessels, you stop the expansion of fat tissue. This is why antiangiogenic drugs can shrink fat.
GoodSupportsHIGH confidence
neovascularization and adipogenesis are temporally and spatially coupled processes... Activated adipocytes produce multiple angiogenic factors... which either alone or collectively stimulate neovascularization during fat mass expansion.
Why this rating
Supported by multiple studies cited in the review showing coupling of processes and effects of inhibitors.
Source
Angiogenesis modulates adipogenesis and obesity
Yihai Cao · Journal of Clinical Investigation · 2007
DOI 10.1172/jci32239
narrative_reviewCited 733×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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