Research
Micronutrients & recovery
Specific gut bacteria, particularly Akkermansia muciniphila and those producing short-chain fatty acids (SCFAs) like butyrate, protect gut barrier integrity and reduce inflammation, whereas HFD reduces their abundance.
Feeding your gut bacteria fiber and prebiotics can increase beneficial bacteria like Akkermansia and butyrate producers, which strengthen your gut lining and reduce inflammation.
GoodSupportsHIGH confidence
A. muciniphila... is strongly correlated with leanness, insulin sensitivity, and reduced low-grade inflammation... Butyrate... is anti-inflammatory by stimulating... PPAR-γ, which leads to... NF-κB pathway inhibition.
Why this rating
Supported by multiple studies cited in the review.
Source
High-Fat, Western-Style Diet, Systemic Inflammation, and Gut Microbiota: A Narrative Review
Ida Malesza et al. · Cells · 2021
DOI 10.3390/cells10113164
narrative_reviewCited 727×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- A high-fat, Western-style diet (HFD) causes systemic low-grade inflammation through gut dysbiosis, increased intestinal permeability (leaky gut), and subsequent translocation of lipopolysaccharide (LPS) into the bloodstream, which activates the TLR4/NF-κB inflammatory pathway.Good
- Lipopolysaccharide (LPS) translocation from the gut to the blood (metabolic endotoxemia) is a key driver of systemic inflammation, mediated by the TLR4 receptor, and is directly caused by HFD-induced gut barrier dysfunction.Good
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