Micronutrients & recovery
Resveratrol exhibits low oral bioavailability of the free compound in humans, with plasma concentrations of free resveratrol remaining below 10 ng/mL (<40 nM) even after high-dose supplementation, while metabolites reach significantly higher concentrations.
If you take resveratrol supplements, do not expect high levels of the raw compound in your bloodstream. The body rapidly metabolizes it into other forms. While the free form is low, the total amount of resveratrol-related compounds in your blood is significant, suggesting the benefits may come from these metabolites or their conversion in tissues, not just the pill itself.
Approximate calculations showed maximal concentrations of <10 ng/mL (≈40 nM), 0.5–2 hours after the oral dose. Estimates of the plasmatic concentrations of resveratrol plus total metabolites were considerably higher, around 400–500 ng/mL (≈2 𝜇M), indicating a very low oral bioavailability of free resveratrol, but a significant one of its metabolites [37, 49].
Why this rating
Based on multiple human pharmacokinetic studies cited (refs 37, 49, 50, 54) showing consistent low free plasma levels.
Source
Properties of Resveratrol:<i>In Vitro</i>and<i>In Vivo</i>Studies about Metabolism, Bioavailability, and Biological Effects in Animal Models and Humans
Juan Gambini et al. · Oxidative Medicine and Cellular Longevity · 2015
DOI 10.1155/2015/837042
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