Research
Micronutrients & recovery
Oral Nicotinamide Riboside (NR) is uniquely and highly bioavailable in humans and mice, significantly elevating blood and hepatic NAD+ levels with superior pharmacokinetics compared to Nicotinic Acid (NA) and Nicotinamide (Nam).
Take Nicotinamide Riboside (NR) orally. Clinical trials show it safely raises NAD+ levels in humans, with effects seen at doses of 100mg to 1,000mg. It appears more effective at boosting NAD+ than common alternatives like Nicotinamide.
GoodSupportsHIGH confidence
Nicotinamide riboside (NR) is uniquely and orally bioavailable in mice and humans... We report that human blood NAD+ can rise as much as 2.7-fold with a single oral dose of NR in a pilot study of one individual, and that oral NR elevates mouse hepatic NAD+ with distinct and superior pharmacokinetics to those of nicotinic acid and nicotinamide.
Why this rating
Includes human clinical trials (n=12) and extensive mouse models, though the pilot human study was n=1.
Source
Nicotinamide riboside is uniquely and orally bioavailable in mice and humans
Samuel A.J. Trammell et al. · Nature Communications · 2016
DOI 10.1038/ncomms12948
clinical_trial · n=13Cited 699×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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