Macro partitioning
The Mediterranean Diet (MedDiet) significantly improves liver health biomarkers (ALT, liver stiffness, and MRI-PDFF) in individuals with MASLD.
Adhering to a Mediterranean Diet significantly improves liver health in people with MASLD, lowering liver enzymes, reducing liver stiffness, and decreasing liver fat content. Studies lasted from 3 to 24 months, showing consistent benefits. This dietary pattern is a strong, evidence-based first-line approach for managing liver health.
The Mediterranean diet (MedDiet) resulted in significant differences in ALT (MD = − 2.93 IU/L; 95% CI − 5.68, − 0.19; p = 0.04; n = 9), liver stiffness (MD = − 0.35 kPa; 95% CI − 0.54, − 0.16; p = 0.00; n = 4), and MRI-PDFF (MD = − 1.37%; 95% CI − 2.33, − 0.40; p = 0.01; n = 5).
Why this rating
Meta-analysis of 9 RCTs for ALT, 4 for stiffness, 5 for PDFF with moderate to high certainty of evidence.
Source
The impact of dietary interventions on liver health biomarkers in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD): a systematic literature review and meta-analysis of randomized controlled trials
Ute Stern et al. · European Journal of Nutrition · 2026
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