Research

Mixed

Phenotypic Age, a composite metric derived from nine clinical chemistry biomarkers and chronological age, serves as a robust predictor of all-cause and cause-specific mortality risk across diverse demographic and health subpopulations, outperforming traditional risk factors like BMI and disease count.

Use a comprehensive clinical panel (including CRP, glucose, albumin, etc.) to calculate a 'Phenotypic Age' rather than relying solely on your birth year. This metric provides a more accurate assessment of your mortality risk and can help identify at-risk individuals earlier than traditional tools like BMI or disease count alone.

GoodSupportsHIGH confidence
Phenotypic Age was significantly associated with all-cause mortality and cause-specific mortality... Results for all-cause mortality were robust to stratifications by age, race/ethnicity, education, disease count, and health behaviors.
Zuyun Liu et al. · PLoS Medicine · 2018

Why this rating

Large, nationally representative cohort (NHANES IV, n=11,432) with long follow-up (12.6 years) and rigorous statistical adjustment.

Source

A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort study

Zuyun Liu et al. · PLoS Medicine · 2018

DOI 10.1371/journal.pmed.1002718

cohort · n=11617Cited 688×
Read the paper
DOI resolved against Crossref · corpus check 2026-06-10

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