Research
Hormonal
Antihistaminergic drugs, antipsychotics, fast-release melatonin, ramelteon, and phytotherapeutics are not recommended for insomnia treatment.
Avoid using antihistamines, antipsychotics, fast-release melatonin, ramelteon, or herbal supplements for treating insomnia, as they are not recommended by current guidelines.
WeakRefutesHIGH confidence
Antihistaminergic drugs, antipsychotics, fast-release melatonin, ramelteon and phytotherapeutics are not recommended for insomnia treatment (A).
Why this rating
Graded as 'A' (very strong recommendation) against their use.
Source
The European Insomnia Guideline: An update on the diagnosis and treatment of insomnia 2023
Dieter Riemann et al. · Journal of Sleep Research · 2023
DOI 10.1111/jsr.14035
clinical_guidelineCited 685×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Cognitive-behavioral therapy for insomnia (CBT-I) is recommended as the first-line treatment for chronic insomnia in adults, regardless of comorbidities, and can be delivered face-to-face or digitally.Weak
- Benzodiazepines, benzodiazepine receptor agonists, and daridorexant are recommended for short-term treatment of insomnia (≤ 4 weeks), while orexin receptor antagonists may be used for up to 3 months or longer in some cases.Weak
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