Micronutrients & recovery
Daily supplementation with 1 gram of n-3 fatty acids (460 mg EPA and 380 mg DHA) does not significantly reduce the risk of serious vascular events in patients with diabetes mellitus without established cardiovascular disease.
If you have diabetes but no known heart disease, taking 1 gram of fish oil daily (providing 460mg EPA and 380mg DHA) will not significantly lower your risk of heart attacks, strokes, or vascular death compared to taking a placebo. This large, long-term study suggests that routine supplementation with these specific doses is not an effective strategy for preventing cardiovascular events in this group.
Among patients with diabetes without evidence of cardiovascular disease, there was no significant difference in the risk of serious vascular events between those who were assigned to receive n−3 fatty acid supplementation and those who were assigned to receive placebo.
Why this rating
Large-scale, randomized, double-blind, placebo-controlled trial (ASCEND) with 15,480 participants and a mean follow-up of 7.4 years.
Source
Effects of n−3 Fatty Acid Supplements in Diabetes Mellitus
The ASCEND Study Collaborative Group · New England Journal of Medicine · 2018
DOI 10.1056/nejmoa1804989
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