Research
Energy balance
Mitochondrial dysfunction and ectopic lipid accumulation (triglycerides in muscle and liver) contribute to insulin resistance by reducing oxidative activity and ATP synthesis, leading to intramyocellular fat accumulation.
Improving mitochondrial health through regular physical activity, particularly aerobic exercise, can help clear ectopic fat from muscles and liver, thereby improving insulin sensitivity.
GoodSupportsHIGH confidence
A decrease in mitochondrial function might be associated with insulin resistance and T2DM since it facilitates the ectopic accumulation of fat in muscles and adipose tissues... These might cause a decrease in the indicators of a decrease as peroxisome proliferator-activated function of mitochondria... and ATP synthesis
Why this rating
Supported by multiple studies cited in the review, showing consistent links between mitochondrial markers and insulin resistance.
Source
<p>Obesity, Insulin Resistance, and Type 2 Diabetes: Associations and Therapeutic Implications</p>
Yohannes Tsegyie Wondmkun · Diabetes Metabolic Syndrome and Obesity · 2020
DOI 10.2147/dmso.s275898
narrative_reviewCited 680×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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