Hormonal
Activation of the estrogen-related receptor alpha (Errα) by PGC-1α drives the expression of oxidative phosphorylation (OXPHOS) genes in skeletal muscle, and this pathway is downregulated in diabetic muscle.
This research identifies Errα as a critical 'switch' for mitochondrial energy production in muscle, which is often stuck 'off' in diabetes. While no direct supplement is named, the findings suggest that therapies activating Errα (agonists) could improve insulin sensitivity and energy metabolism in diabetic muscle without affecting liver glucose production.
Errα and Gabpa/b specify PGC-1α-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle
Why this rating
Strong computational and cellular validation (C2C12 myotubes), but lacks human clinical trial data.
Source
Errα and Gabpa/b specify PGC-1α-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle
Vamsi K. Mootha et al. · Proceedings of the National Academy of Sciences · 2004
DOI 10.1073/pnas.0401401101
More from this paper
- Inhibition of Errα using the synthetic inverse agonist XCT790 reduces PGC-1α-mediated cellular respiration and OXPHOS gene expression in muscle cells.Good
- Errα and Gabpa form a double-positive-feedback loop with PGC-1α to drive robust expression of mitochondrial genes, and this loop is disrupted in diabetic muscle.Good
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