Research
Hormonal
Errα and Gabpa form a double-positive-feedback loop with PGC-1α to drive robust expression of mitochondrial genes, and this loop is disrupted in diabetic muscle.
Diabetic muscle has a broken feedback loop between PGC-1α, Errα, and Gabpa. Restoring this loop, potentially via Errα agonists, could improve mitochondrial function.
GoodSupportsHIGH confidence
Cellular assays confirmed that Errα and GA-binding protein a partner with PGC-1α in muscle to form a double-positive-feedback loop that drives the expression of many OXPHOS genes.
Why this rating
Strong computational and cellular validation.
Source
Errα and Gabpa/b specify PGC-1α-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle
Vamsi K. Mootha et al. · Proceedings of the National Academy of Sciences · 2004
DOI 10.1073/pnas.0401401101
mechanism_onlyCited 679×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Activation of the estrogen-related receptor alpha (Errα) by PGC-1α drives the expression of oxidative phosphorylation (OXPHOS) genes in skeletal muscle, and this pathway is downregulated in diabetic muscle.Good
- Inhibition of Errα using the synthetic inverse agonist XCT790 reduces PGC-1α-mediated cellular respiration and OXPHOS gene expression in muscle cells.Good
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