Mixed
Long-term calorie restriction (CR) prevents age-related large artery stiffening and endothelial dysfunction by reducing oxidative stress and inflammation.
To improve vascular health and slow aging, consider reducing your daily caloric intake by 25% while ensuring you get all necessary nutrients. This approach, validated by the CALERIE trial, has been shown to reduce cardiovascular risk factors and slow biological aging in nonobese adults.
long-term calorie restriction—a health span- and life span-extending intervention—can prevent many of these age-related vascular phenotypes through the prevention of deleterious alterations in these mechanisms.
Why this rating
Supported by animal models, non-human primate studies, and the CALERIE human trial, though long-term human data on stiffness is less robust than animal data.
Source
Mechanisms of Dysfunction in the Aging Vasculature and Role in Age-Related Disease
Anthony J. Donato et al. · Circulation Research · 2018
DOI 10.1161/circresaha.118.312563
Related findings · Mixed
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