Mixed
The DunedinPoAm DNA methylation algorithm accurately quantifies the pace of biological aging (rate of decline in system integrity) rather than just chronological age, serving as a valid surrogate endpoint for testing interventions that slow aging.
This paper introduces a blood test (DunedinPoAm) that measures how fast your body is aging biologically, distinct from your chronological age. It is currently a research tool used to validate interventions like caloric restriction (CALERIE trial) that slow aging. For now, it is not a commercial consumer product, but it validates that slowing biological aging is measurable and that interventions like calorie restriction can impact this rate.
We report a blood-DNA-methylation measure that is sensitive to variation in pace of biological aging among individuals born the same year... Validation analysis in cohort studies and the CALERIE trial provide proof-of-principle for DunedinPoAm as a single-time-point measure of a person’s pace of biological aging.
Why this rating
Strong validation across multiple longitudinal cohorts (Dunedin, Understanding Society, NAS, E-Risk) and a randomized controlled trial (CALERIE), though it is a new algorithm requiring further replication.
Source
Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm
Daniel W. Belsky et al. · eLife · 2020
DOI 10.7554/elife.54870
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →