Research
Hormonal
GLP-1 receptor agonists (specifically Liraglutide 3.0 mg/day) induce significant weight loss (median 63% achieving ≥5% loss) and reduce hepatic steatosis, potentially through mechanisms independent of weight loss.
If lifestyle changes are insufficient, GLP-1 receptor agonists like Liraglutide (3.0 mg/day) are highly effective. They help patients lose significant weight (average 8%) and directly reduce liver fat and inflammation. This is particularly relevant for patients with Type 2 Diabetes.
GoodSupportsHIGH confidence
Liraglutide 3.0 mg/day has proven to induce 8.0 ± 6.7% of weight loss [105] and 63% median rate of achieving at least 5% weight loss [106]. ... some of the beneficial effects of liraglutide on NAFLD could be independent of weight loss. In rodents, liraglutide prevented the development of NAFLD and attenuated the expression of pro-inflammatory cytokines [107–110].
Why this rating
Cites RCTs and meta-analyses (refs 105-110), though many are in T2D patients.
Source
NAFLD as a continuum: from obesity to metabolic syndrome and diabetes
Amélio F. Godoy‐Matos et al. · Diabetology & Metabolic Syndrome · 2020
DOI 10.1186/s13098-020-00570-y
narrative_reviewCited 638×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
Related findings · Hormonal
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