Energy balance
Weight loss of 7-10% is the primary therapeutic target for NAFLD, as it resolves NASH in 65-90% of patients and improves fibrosis in 45% of patients.
To reverse fatty liver disease (NASH), you need to lose 7-10% of your body weight. Losing just 3-5% helps reduce liver fat, but you need the higher 7-10% range to resolve the inflammation and scarring. Focus on a Mediterranean-style diet and avoid snacking to achieve a steady loss of 0.5-1 kg per week.
Seven percent or more of weight loss resolves NASH in 65–90% of patients and improves the NAS [78–80]. Ten percent or more, can improve fibrosis, leading to fibrosis regression in 45% of patients [77, 79]. ... according to the NAFLD guidelines, a 7–10% weight loss is the primary target of most interventions [5, 6].
Why this rating
Based on meta-analyses and guidelines cited (refs 77-80), though specific primary RCT data is summarized rather than detailed.
Source
NAFLD as a continuum: from obesity to metabolic syndrome and diabetes
Amélio F. Godoy‐Matos et al. · Diabetology & Metabolic Syndrome · 2020
DOI 10.1186/s13098-020-00570-y
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