Mixed
Activation of the Nrf2 signaling pathway promotes mitochondrial biogenesis, thereby supporting active longevity and mitigating age-related mitochondrial dysfunction.
To support active longevity, engage in activities that mildly stress the body, such as moderate physical exercise. This stress activates the Nrf2 pathway, which in turn boosts mitochondrial biogenesis (the creation of new mitochondria) and improves cellular energy efficiency. This process helps counteract age-related decline in mitochondrial function.
In this review, we summarized recent data on the Nrf2 role in mitochondrial biogenesis and its interaction with PGC-1α in the context of extending longevity.
Why this rating
This is a review paper summarizing multiple animal and cell studies; no primary clinical trial data is presented.
Source
Regulation of Mitochondrial Biogenesis as a Way for Active Longevity: Interaction Between the Nrf2 and PGC-1α Signaling Pathways
Artem P. Gureev et al. · Frontiers in Genetics · 2019
DOI 10.3389/fgene.2019.00435
More from this paper
- Physical exercise induces Nrf2-dependent mitochondrial biogenesis in skeletal muscle and the brain, contributing to neuroprotection and metabolic health.Moderate
- Nrf2 and PGC-1α form a bidirectional regulatory loop where Nrf2 influences PGC-1α expression, and PGC-1α activates Nrf2, jointly regulating mitochondrial biogenesis.Moderate
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