Research

Micronutrients & recovery

Low circulating 25-hydroxy-vitamin D levels (below approximately 60 nmol/L) are associated with a linear increase in the risk of cardiovascular disease, including total CVD, coronary heart disease, stroke, and CVD mortality.

Maintaining adequate vitamin D levels (around 60 nmol/L or higher) is associated with a lower risk of cardiovascular disease. However, this is an observational finding, so simply taking high-dose supplements is not proven to prevent heart disease. Focus on general health guidelines for vitamin D intake rather than using it as a standalone heart disease prevention strategy.

GoodSupportsHIGH confidence
The CVD risk increased monotonically across decreasing 25(OH)-vitamin D below ≈60 nmol/L, with a relative risk of 1.03 (95% confidence interval, 1.00–1.06) per 25-nmol/L decrement in 25(OH)-vitamin D.
Lu Wang et al. · Circulation Cardiovascular Quality and Outcomes · 2012

Why this rating

Meta-analysis of 19 prospective studies with large sample size (65,994 participants) and consistent inverse associations, though heterogeneity exists.

Source

Circulating 25-Hydroxy-Vitamin D and Risk of Cardiovascular Disease

Lu Wang et al. · Circulation Cardiovascular Quality and Outcomes · 2012

Meta-analysis · 19 studiesCited 614×
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