Research
Mixed
The combination of high leisure time sitting (>=6 hours/day) and low physical activity (<24.5 MET-hours/week) is associated with a substantially higher risk of all-cause mortality compared to low sitting and high physical activity.
Your health risk is highest when you sit for 6+ hours a day AND exercise less than 24.5 MET-hours per week. To minimize this risk, aim to sit less than 3 hours a day and engage in at least 24.5 MET-hours of physical activity weekly. This dual approach offers the greatest protection against mortality.
GoodSupportsHIGH confidence
Relative risks for sitting (>=6 hours/day) and physical activity (<24.5 metabolic equivalent (MET)-hours/week) combined were 1.94 (95% CI: 1.70, 2.20) for women and 1.48 (95% CI: 1.33, 1.65) for men, compared with those with the least time sitting and most activity.
Why this rating
Large cohort, clear dose-response relationship, robust statistical adjustment.
Source
Leisure Time Spent Sitting in Relation to Total Mortality in a Prospective Cohort of US Adults
Alpa V. Patel et al. · American Journal of Epidemiology · 2010
DOI 10.1093/aje/kwq155
cohort · n=123216Cited 607×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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