Hormonal
Leptin administration effectively reverses hyperphagia and obesity in humans with congenital leptin deficiency, but has only modest and variable effects on body weight in obese individuals with normal or high leptin levels.
If you have been diagnosed with a rare genetic inability to produce leptin, leptin therapy is life-saving and effective. However, for the vast majority of people with common obesity, taking leptin supplements will not work because your body has developed resistance to the hormone. Focus on mechanisms that improve insulin sensitivity and metabolic health rather than seeking leptin as a direct weight-loss drug.
Humans genetically lacking leptin are also hyperphagic and severely obese and respond dramatically to leptin administration... leptin administration to obese humans only has a modest and variable effect on body weight.
Why this rating
Based on genetic knockout models and clinical trials in specific patient populations, though general obesity trials show variable results.
Source
The Hormonal Control of Food Intake
Anthony P. Coll et al. · Cell · 2007
DOI 10.1016/j.cell.2007.04.001
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