Research
Hormonal
Peripheral administration of PYY3-36 reduces food intake, and bariatric surgery works in part by causing an exaggerated postprandial PYY3-36 surge.
If you undergo bariatric surgery, part of why it works is that your body releases more PYY3-36, a hormone that makes you feel full. This hormonal change helps maintain weight loss long-term, complementing the physical restriction of the surgery.
GoodSupportsHIGH confidence
peripherally administered PYY3–36 can reduce food intake... bariatric surgery results in an exaggerated postprandial PYY3–36 surge, potentially explaining the effectiveness of such surgery in maintaining a prolonged reduction in postoperative weight.
Why this rating
Supported by human studies showing correlation with surgery outcomes and mouse models.
Source
The Hormonal Control of Food Intake
Anthony P. Coll et al. · Cell · 2007
DOI 10.1016/j.cell.2007.04.001
narrative_reviewCited 597×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Genetic mutations in the Melanocortin-4 Receptor (MC4R) are a common cause of severe childhood and adult obesity, resulting in hyperphagia and increased fat and lean mass.Strong
- Leptin administration effectively reverses hyperphagia and obesity in humans with congenital leptin deficiency, but has only modest and variable effects on body weight in obese individuals with normal or high leptin levels.Good
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →