Energy balance
The Trp64Arg missense mutation in the beta3-adrenergic receptor gene is associated with an earlier onset of non-insulin-dependent diabetes mellitus (NIDDM) in Pima Indians, specifically in those homozygous for the mutation.
If you have the Trp64Arg mutation in your beta3-adrenergic receptor gene (particularly if you are homozygous), you are genetically predisposed to develop type 2 diabetes at a younger age. This is linked to a slightly lower resting metabolic rate. You should prioritize regular metabolic screening and focus on maintaining energy balance through diet and physical activity to counteract this genetic tendency, rather than assuming diabetes is inevitable.
Among Pimas, the frequency of the Trp64Arg mutation was similar in nondiabetic and diabetic subjects. However, in subjects homozygous for the mutation the mean (SD) age at the onset of NIDDM was significantly lower (36+/-10 years) than in Trp64Arg heterozygotes (40+/-10 years) or normal homozygotes (41+/-11 years; P<0.02).
Why this rating
The study uses a large, well-defined population (Pima Indians) with rigorous genetic and metabolic measurements, though it is an observational association study rather than a randomized trial.
Source
Time of Onset of Non-Insulin-Dependent Diabetes Mellitus and Genetic Variation in the β<sub>3</sub>-Adrenergic–Receptor Gene
Jeremy Walston et al. · New England Journal of Medicine · 1995
DOI 10.1056/nejm199508103330603
Related findings · Energy balance
- Achieving a total body weight loss of 10-15% (or >10-15 kg) through Total Diet Replacement (TDR) induces remission of Type 2 Diabetes in individuals with short-duration disease.Strong
- Bariatric surgery is superior to medical management alone for inducing significant long-term weight loss, remission of type 2 diabetes, and reduction in mortality for patients with BMI ≥ 40 or ≥ 35 with comorbidities.Strong
- Achieving type 2 diabetes remission requires significant weight loss (≥15 kg) via major caloric restriction, independent of macronutrient composition.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →