Research

Energy balance

High-protein diets increase energy expenditure (thermogenesis) primarily through the ATP costs of protein synthesis, urea synthesis, and gluconeogenesis, with complete proteins potentially inducing a larger increase than lower-quality proteins.

Eating more protein slightly boosts your metabolism because your body uses more energy to process it. This effect is real but modest compared to the benefit of feeling fuller. Don't rely on this 'thermic effect' alone for weight loss, but view it as a helpful bonus.

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Protein-induced energy expenditure may be due to protein and urea synthesis and to gluconeogenesis; 'complete' proteins having all essential amino acids show larger increases in energy expenditure than do lower-quality proteins.
Margriet S. Westerterp‐Plantenga et al. · Annual Review of Nutrition · 2009

Why this rating

Supported by respiration chamber studies and computational models cited in the review.

Source

Dietary Protein, Weight Loss, and Weight Maintenance

Margriet S. Westerterp‐Plantenga et al. · Annual Review of Nutrition · 2009

DOI 10.1146/annurev-nutr-080508-141056

narrative_reviewCited 571×
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DOI resolved against Crossref · corpus check 2026-06-10

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