Mixed
Pharmacological elimination of senescent cells (senolytics) or suppression of their secretory phenotype (senomorphics) delays or alleviates multiple age-related pathologies and extends healthspan in animal models.
Current research suggests that clearing senescent cells may help delay age-related diseases. However, effective treatments are still in clinical trials. Do not attempt to self-medicate with unproven supplements claiming to be 'senolytics' without medical supervision, as efficacy and safety are not yet established for general use.
Importantly, removal of SnCs, or suppression of the SASP, can alleviate or delay multiple chronic age-related conditions, demonstrating the therapeutic potential of targeting SnCs.
Why this rating
Strong preclinical evidence in multiple mouse models; clinical trials are ongoing but results are mixed or early stage.
Source
Cellular senescence: a key therapeutic target in aging and diseases
Lei Zhang et al. · Journal of Clinical Investigation · 2022
DOI 10.1172/jci158450
Related findings · Mixed
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