Research
Micronutrients & recovery
Antioxidants yield conflicting results and are heterogeneous regarding type, dose, and duration, making them less reliable than weight loss or TZDs.
Antioxidant supplements do not have consistent, reliable results for treating NASH. The evidence is mixed, and they are not as effective as weight loss. Do not rely on them as a primary treatment.
ModerateRefutesMEDIUM confidence
RCTs with antioxidants yielded conflicting results and were heterogeneous with respect to type and dose of drug, duration, implementation of lifestyle intervention.
Why this rating
Meta-analysis shows high heterogeneity and conflicting results.
Source
A Meta-Analysis of Randomized Trials for the Treatment of Nonalcoholic Fatty Liver Disease
Giovanni Musso et al. · Hepatology · 2010
DOI 10.1002/hep.23623
Meta-analysis · 49 studiesCited 565×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Weight loss improves histological disease activity in NASH in a dose-dependent manner, although more than 50% of patients fail to achieve the target weight loss.Good
- Thiazolidinediones (specifically pioglitazone) improve liver steatosis and inflammation but cause significant weight gain.Good
- Polyunsaturated fatty acids (PUFA) improve biochemical and radiological markers of NAFLD.Moderate
Related findings · Micronutrients & recovery
- Trans fats (industrial trans-fatty acids) are unequivocally harmful and should be completely avoided as they raise LDL-C, TGs, and Apo B while lowering HDL-C.Strong
- For menopausal women with osteoporosis, first-line pharmacologic therapies include alendronate, risedronate, zoledronic acid, and denosumab for the prevention of hip, nonvertebral, and vertebral fractures.Strong
- Folic acid fortification of flour prevents neural tube birth defects, and mandatory fortification is more effective than voluntary supplementation alone.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →