Research
Energy balance
Caloric restriction and fasting reduce circulating ob protein and ob mRNA levels in a manner consistent with the reduction in adipose mass.
When you fast or significantly restrict calories, your body produces much less of this fat-regulating hormone. This drop in hormone levels is a normal physiological response to low energy stores and helps signal the brain to conserve energy.
GoodSupportsHIGH confidence
In the ob/ob, UCP-DTA and MSG models, overexpression of ob mRNA is reversed by caloric restriction.
Why this rating
Consistent findings across multiple models showing reversible suppression of ob with fasting.
Source
Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity.
Robert Frederich et al. · Journal of Clinical Investigation · 1995
DOI 10.1172/jci118206
mechanism_onlyCited 562×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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