Mixed
Combining sibutramine pharmacotherapy with intensive group lifestyle modification counseling produces significantly greater weight loss than either intervention administered alone.
If you are using prescription weight-loss medication, do not rely on it alone. You must combine it with intensive lifestyle counseling, specifically focusing on behavioral skills like keeping daily food records. The study shows that combining the drug with 30 weeks of group counseling leads to more than double the weight loss compared to using the drug alone.
The combination of medication and group lifestyle modification resulted in more weight loss than either medication or lifestyle modification alone.
Why this rating
Randomized controlled trial with 224 subjects, published in the New England Journal of Medicine, with statistically significant results (P<0.001).
Source
Randomized Trial of Lifestyle Modification and Pharmacotherapy for Obesity
Thomas A. Wadden et al. · New England Journal of Medicine · 2005
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