Mixed
Primary Obesity Surgery Endoluminal (POSE) 2.0 and Endomina Gastric Plication are effective endoscopic gastric remodeling techniques that produce significant weight loss and metabolic improvements, though with varying efficacy profiles compared to ESG.
POSE 2.0 and Endomina are endoscopic options that use full-thickness plications to reduce stomach size. They are effective for weight loss and metabolic improvement, though ESG may offer higher weight loss percentages in some studies. They are suitable for patients seeking minimally invasive alternatives to surgery.
The initial result of the POSE 2.0 procedure with 73 obese patients showed a TWL of 15.7% at 6 months... An international multicenter randomized controlled study (INSPIRO trial) has recently been approved by the FDA... An initial multicenter prospective study involved 51 patients... who underwent Endomina gastric plication. After one year, the participants achieved a TWL of 7.4% and an EWL of 29%.
Why this rating
Supported by prospective studies and RCTs, but sample sizes are smaller than ESG cohorts, and long-term data is less extensive.
Source
Endoscopic gastric remodeling procedures for obesity treatment: a comprehensive review
Stephen Ka Kei Ng et al. · Metabolism and Target Organ Damage · 2025
DOI 10.20517/mtod.2024.112
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
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