Hormonal
A simple index derived from the first 30 minutes of an Oral Glucose Tolerance Test (OGTT), calculated as the product of the area under the curve (AUC) for glucose and insulin, accurately quantifies hepatic (liver) insulin resistance.
If you are at risk for diabetes or metabolic syndrome, a standard Oral Glucose Tolerance Test (OGTT) can reveal liver-specific insulin resistance. By analyzing the first 30 minutes of your blood sugar and insulin response, doctors can identify liver dysfunction earlier and more accurately than with fasting tests alone, allowing for targeted lifestyle or medical interventions to prevent type 2 diabetes.
The product of total area under curve (AUC) for glucose and insulin during the first 30 min of the OGTT (glucose0 –30[AUC] * insulin0 –30[AUC]) strongly correlated with the hepatic insulin resistance index (fasting plasma insulin * basal endogenous glucose production) (r = 0.64, P < 0.0001).
Why this rating
Strong correlation (r=0.64) with the gold-standard insulin clamp method in a large, diverse cohort (n=155).
Source
Muscle and Liver Insulin Resistance Indexes Derived From the Oral Glucose Tolerance Test
Muhammad Abdul-Ghani et al. · Diabetes Care · 2006
DOI 10.2337/dc06-1519
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