Hormonal
A specific index derived from the decline phase of an Oral Glucose Tolerance Test (OGTT), calculated as the rate of glucose decline divided by mean insulin concentration, accurately quantifies skeletal muscle insulin sensitivity.
If you are at risk for diabetes or metabolic syndrome, a standard Oral Glucose Tolerance Test (OGTT) can reveal muscle-specific insulin resistance. By analyzing how quickly your blood sugar drops after the peak and dividing that by your insulin levels, doctors can identify muscle dysfunction earlier and more accurately than with fasting tests alone, allowing for targeted lifestyle or medical interventions to prevent type 2 diabetes.
The rate of decay of plasma glucose concentration from its peak value to its nadir during the OGTT divided by the mean plasma insulin concentration (dG/dt / I) strongly correlated with muscle insulin sensitivity measured with the insulin clamp (r = 0.78, P < 0.0001).
Why this rating
Stronger correlation (r=0.78) with the gold-standard insulin clamp method compared to the hepatic index, in a large, diverse cohort.
Source
Muscle and Liver Insulin Resistance Indexes Derived From the Oral Glucose Tolerance Test
Muhammad Abdul-Ghani et al. · Diabetes Care · 2006
DOI 10.2337/dc06-1519
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